Malaria Host Pathogen Interaction Center (MaHPIC) Experiment 25 (E25) Clinical Results

Experiment 25: Macaca mulatta infected with Plasmodium cynomolgi strain ceylonensis, in a heterologous challenge, to produce and integrate clinical, hematological, parasitological, and omics measures of acute primary infection and relapses. This clinical results dataset contains measures of disease infection including counts and calucations for: CBCs, reticulocytes, parasitemias, and downstream immunological, functional genomic, lipidomic, proteomic, and metabolomic measurements. Results also include data and metadata from veterinarians on all facets of animal access, including, but not limited to: treatments, hematology, biochemical analyses, parasitology, bacteriology, and surgery statistics, etc. Results also include documentation of data collection and analysis methods and supporting clinical matarials that differentiate between 'Idealized' and 'Actual' disease progression. This is the third in a series of experiments that includes infection of malaria-naïve subjects (Experiment 23, P. cynomolgi B strain) and homologous challenge (Experiment 24, P. cynomolgi B strain) for the individuals from the same cohort. Subjects were cleared of previous infection with  P. cynomolgi B strain via treatment with the anti-malarial drugs artemether, chloroquine, and primaquine. Please see the file 'E25M99MEMmCyDaWB_README-PlasmoDB-09262018-V1_MULTIPL.txt' for a full description of this dataset and for instructions on how to access other datasets from this experiment. Please see https://plasmodb.org/plasmo/mahpic.jsp for descriptions and locations of all public MaHPIC datasets.

Data and Resources

Additional Info

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Author Jessica C Kissinger, Alberto Moreno, Mary R Galinski
Version 1.0
Last Updated June 23, 2024, 17:07 (UTC)
Created June 23, 2024, 17:07 (UTC)
Citation Jessica C Kissinger, Alberto Moreno, Mary R Galinski 2019. Malaria Host Pathogen Interaction Center (MaHPIC) Experiment 25 (E25) Clinical Results. CyVerse Data Commons. DOI 10.25739/70ze-8c03
Date created in discovery environment 2019-10-21 20:26:21
Date last modified in discovery environment 2020-02-20 22:05:33
alternateIdentifier https://plasmodb.org/common/downloads/MaHPIC/Experiment_25/
contributor Jeremy D DeBarry
format txt, pdf, xlsx, png
fundingReference HHSN272201200031, National Institutes of Health
identifierType DOI
publisher CyVerse Data Commons
resourceType Clinical Results Dataset
reuse_or_citation_conditions Please include the DOI when citing this dataset. Please refer to https://plasmodb.org/plasmo/mahpic.jsp for more information.
size 4.3 MB